abstract：BACKGROUND:The De Gramont regimen (or high-dose LV5FU2, HD-LV5FU2) is considered a standard treatment for metastatic colorectal cancer. The aim of the study was to evaluate the efficacy and the costs of three regimens as compared to HD-LV5FU2: raltitrexed (R), LV5FU2 with a lower dose of folinic acid (LD-LV5FU2), and w...

journal_title：Oncology

authors： Borget I,Aupérin A,Pignon JP,Abbas M,Bouché O,Mousseau M,Raoul JL,Bedenne L,Cassan P,Clavero-Fabri MC,Stremsdoerfer N,Nasca S,Queuniet AM,Ducreux M,Fédération Francophone de Cancérologie Digestive.

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVES:Recently, it has been reported that expression of the HRK gene was significantly reduced by hypermethylation in astrocytic tumors. Our aim is to verify the alterations in the HRK gene in primary central nervous system lymphomas (PCNSLs). METHODS:We analyzed the hypermethylation status and expression of the ...

journal_title：Oncology

authors： Nakamura M,Ishida E,Shimada K,Nakase H,Sakaki T,Konishi N

更新日期：2006-01-01 00:00:00

abstract：:Capecitabine is converted to 5-fluorouracil by thymidine phosphorylase, and mitomycin C is capable of upregulating the expression of thymidine phosphorylase suggesting a synergistic effect. Fifty-three patients (median age 62 years) with anthracycline- and taxane-resistant, metastatic breast cancer received mitomycin ...

journal_title：Oncology

authors： Massacesi C,La Cesa A,Marcucci F,Pilone A,Rocchi MB,Zepponi L,Santini D,Tonini G,Burattini L

更新日期：2006-01-01 00:00:00

abstract：:In squamous cell carcinoma of the head and neck (SCCHN), hypoxia is considered a crucial physiological modulator for malignant progression, wherebythe plasminogen activation system is involved in overlapping functions such as moulding of the extracellular matrix, cell proliferation and signal transduction. Little is k...

journal_title：Oncology

authors： Sprague LD,Mengele K,Schilling D,Geurts-Moespot A,Sweep FC,Stadler P,Schmitt M,Molls M

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:In order to broaden the possibility for anti-MAGE-3 immune targeting, it is important to identify HLA-A24-restricted epitopes derived from MAGE-3, since HLA-A24 is one of the most common alleles in Japanese and Asian people. In the present study, we defined a new MAGE-3 derived, HLA-A24-binding peptide presente...

journal_title：Oncology

authors： Miyagawa N,Kono K,Mimura K,Omata H,Sugai H,Fujii H

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:Our aim is to assess the clinicopathological significance of E-cadherin and beta-catenin expression, as well as their association with apoptosis in gallbladder cancers. METHODS:The expression of E-cadherin and beta-catenin proteins was examined in 4 biliary tract cancer cell lines and 49 gallbladder cancer s...

journal_title：Oncology

authors： Hirata K,Ajiki T,Okazaki T,Horiuchi H,Fujita T,Kuroda Y

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:We investigated whether a 5-fluorouracil (5-FU)-resistant tumor could regain chemosensitivity after the administration of 5-aza-2'-deoxycytidine (DAC) as a demethylating agent. METHODS:Human colorectal cancer cells (SW48) are characterized by the hypermethylation of proapoptotic genes. They were transplanted i...

journal_title：Oncology

authors： Morita S,Iida S,Kato K,Takagi Y,Uetake H,Sugihara K

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:We assessed the prognostic value of the nuclear DNA content measured in the primary tumours of 123 patients with stage II or stage III colorectal cancer (CRC). METHODS:Isolated nuclei from paraffin sections were stained with the Feulgen reaction, and DNA was measured using a computer-assisted image analysis...

journal_title：Oncology

authors： Buhmeida A,Algars A,Ristamäki R,Collan Y,Syrjänen K,Pyrhönen S

更新日期：2006-01-01 00:00:00

abstract：:Calcitriol (1,25-dihydroxycholecalciferol) has antiproliferative and/or proapoptotic effects on many cell types and the glucocorticoid dexamethasone enhances these effects. We have shown that calcitriol modulates several key signaling proteins involved in differentiation, proliferation and apoptosis in tumor-derived m...

journal_title：Oncology

authors： Flynn G,Chung I,Yu WD,Romano M,Modzelewski RA,Johnson CS,Trump DL

更新日期：2006-01-01 00:00:00

abstract：:Breast tumorigenesis is a continuum from preinvasive lesions to early breast cancer and advanced disease. In this article the data supporting the use of the aromatase inhibitor anastrozole in postmenopausal women across this continuum are reviewed. In advanced disease, anastrozole has a significant survival benefit an...

journal_title：Oncology

authors： Nabholtz JM

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:Therapeutic decision-making in metastatic renal cell carcinoma (MRCC) is based on conventional radiological evaluation. Fluorodeoxyglucose positron emission tomography (FDG-PET) scans may modify this strategy. METHODS:Patients with MRCC for whom a therapeutic decision had been made underwent an FDG-PET scan ...

journal_title：Oncology

authors： Dilhuydy MS,Durieux A,Pariente A,de Clermont H,Pasticier G,Monteil J,Ravaud A

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:Nucleoside and nucleobase derivatives are currently used in the treatment of a variety of solid tumors; however, the role of plasma membrane transporters as biomarkers of drug metabolism has not been fully addressed. Thus, the purpose of this study was to determine whether the concentrative nucleoside transport...

journal_title：Oncology

authors： Gloeckner-Hofmann K,Guillén-Gómez E,Schmidtgen C,Porstmann R,Ziegler R,Stoss O,Casado FJ,Rüschoff J,Pastor-Anglada M

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:There is much evidence for the detrimental effect of treatment interruptions on tumor control, particularly in head and neck cancer. In order to determine the outcome of the treatment interruptions in postoperative irradiation of breast cancer, 853 female patients treated between 1990 and 1999 inclusive were ...

journal_title：Oncology

authors： Bese NS,Sut PA,Ober A

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:In order to improve the prognosis of pancreatic cancer patients, it is crucial to explore novel tools for its early diagnosis. Here, we attempted to screen serum biomarkers to distinguish pancreatic cancer from non-cancer individuals. METHODS:47 serum samples from pancreatic cancer patients, 39 of whom had s...

journal_title：Oncology

authors： Yu Y,Chen S,Wang LS,Chen WL,Guo WJ,Yan H,Zhang WH,Peng CH,Zhang SD,Li HW,Chen GQ

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Postoperative management of patients with pancreatic adenocarcinoma (PA) is controversial. METHODS:The aim of this pilot study was to assess the feasibility of postoperative combination chemotherapy followed by radiotherapy in patients aged 18-70 years with a histological diagnosis of PA, and Karnofsky perf...

journal_title：Oncology

authors： Reni M,Passoni P,Bonetto E,Balzano G,Panucci MG,Zerbi A,Ronzoni M,Staudacher C,Villa E,Di Carlo V

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:Superficially spreading early gastric cancer is characterized by wide horizontal extension without deep vertical invasion. This study aimed to clarify the clinicopathological characteristics and prognosis of this rare disease. METHODS:We defined superficially spreading early gastric cancer as any tumor inva...

journal_title：Oncology

authors： Kunisaki C,Akiyama H,Nomura M,Matsuda G,Otsuka Y,Ono H,Shimada H

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Bladder cancer is the fifth most common cancer among men and the seventh among women. At diagnosis, at least 25% of bladder cancer tumors are locally or systemically advanced. Systemic chemotherapy is the only current modality for advanced or metastatic transitional cell carcinoma of the bladder. Recently, a...

journal_title：Oncology

authors： Adamo V,Magno C,Spitaleri G,Garipoli C,Maisano C,Alafaci E,Adamo B,Rossello R,Scandurra G,Scimone A

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:The herpes simplex virus thymidine kinase (HSVtk)/ganciclovir suicide gene therapy system has been considered as one of the most promising therapeutic strategies for malignant gliomas. We have been using HSVtk gene-transduced neural stem cells (NSCtk) that possess an ability to migrate toward a tumor mass for...

journal_title：Oncology

authors： Li S,Tokuyama T,Yamamoto J,Koide M,Yokota N,Namba H

更新日期：2005-01-01 00:00:00

abstract：:Stem cell mimicry of cancer cells has been known for a long time and is considered to be responsible for ectopic gene expressions. The stem cell characteristics of tumor cells are shown to be involved in epithelial-mesenchymal transition and in the phenomenon of vascular mimicry. Certain cancer types acquire a geno-ph...

journal_title：Oncology

authors： Tímár J,Tóvári J,Rásó E,Mészáros L,Bereczky B,Lapis K

更新日期：2005-01-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a homodimeric glycoprotein with a molecular weight of approximately 45 kDa. It is the key mediator of angiogenesis (the formation of new blood vessels), and binds two VEGF receptors (VEGF receptor-1 and VEGF receptor-2), which are expressed on vascular endothelial cells. In...

journal_title：Oncology

authors： Carmeliet P

更新日期：2005-01-01 00:00:00

abstract：:As TS-1 and docetaxel (TXT) have different mechanisms of antitumor activity, the combination therapy is expected to have a higher response. Human gastric cancer xenografts SC-2, St-40, and SC-4 inoculated into nude rats were treated with TS-1 alone (TS-1 12 mg/kg/day, day 1-14), TXT alone (TXT 2 mg/kg/day, day 1 or da...

journal_title：Oncology

authors： Takahashi I,Emi Y,Kakeji Y,Uchida J,Fukushima M,Maehara Y

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:Pegylated liposomal doxorubicin (PLD) and capecitabine (CAP) have separately shown significant antitumor activity in a wide range of solid tumors. A phase I study was conducted in order to determine the maximum tolerated dose (MTD) and dose-limiting toxicities (DLTs) of their combination in patients with refr...

journal_title：Oncology

authors： Maltezos E,Amarantidis K,Trichas M,Vasiliadis M,Toromanidou M,Chatzaki E,Karayiannakis A,Tsaroucha A,Romanidis K,Kakolyris S

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:The well-being of oncologists is important to the well-being of their patients. While much is known about oncologist distress, little is known about oncologist well-being. We set out to evaluate oncologist well-being and the personal wellness promotion strategies used by oncologists. PATIENTS AND METHODS:We pe...

journal_title：Oncology

authors： Shanafelt TD,Novotny P,Johnson ME,Zhao X,Steensma DP,Lacy MQ,Rubin J,Sloan J

更新日期：2005-01-01 00:00:00

abstract：:Gastrointestinal stem cells have the capacity for long-term self-replication and the ability to give rise to all other epithelial cell lineages. These properties make them essential since they maintain tissue homeostasis by regulating cell turnover depending on the current demand. However, they are also important play...

journal_title：Oncology

authors： Schier S,Wright NA

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:We recently demonstrated that papillary microcarcinomas with preoperatively detectable node metastasis in the lateral compartment on ultrasonography (clinically apparent metastasis) show worse postoperative relapse-free survival than those with no metastasis or metastasis that could not be detected preoperat...

journal_title：Oncology

authors： Ito Y,Uruno T,Takamura Y,Miya A,Kobayashi K,Matsuzuka F,Kuma K,Miyauchi A

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:N-Acetylglucosaminyltransferase V (GnT-V) is a key enzyme in the formation of branching asparagine-linked oligosaccharides and is linked to tumor invasion and metastasis in colon and breast cancers. In normal esophageal epithelium, beta1,6-branched asparagine-linked oligosaccharides synthesized by GnT-V are s...

journal_title：Oncology

authors： Ishibashi Y,Dosaka-Akita H,Miyoshi E,Shindoh M,Miyamoto M,Kinoshita I,Miyazaki H,Itoh T,Kondo S,Nishimura M,Taniguchi N

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:Early detection of esophageal cancer is hampered by paucity of molecular markers for diagnosis of this aggressive gastrointestinal malignancy in early stages. We recently identified TC21/R-Ras2, a small GTP-binding protein (SMG) in esophageal squamous cell carcinomas (ESCCs) by differential display. This stu...

journal_title：Oncology

authors： Sharma R,Sud N,Chattopadhyay TK,Ralhan R

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:Primary chemoradiotherapy for locally advanced pancreatic cancer (LAPC) may improve local control, curative resection rate and long-term survival. We performed a phase II study to evaluate toxicity and activity of primary radiation therapy and concurrent chemotherapy with gemcitabine (GEM) twice weekly in pa...

journal_title：Oncology

authors： Magnino A,Gatti M,Massucco P,Sperti E,Faggiuolo R,Regge D,Capussotti L,Gabriele P,Aglietta M

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to investigate the longitudinal changes in quality of life (QoL) for patients with advanced stage (stage III or IV) head and neck squamous cell carcinoma (HNSCC) following primary radiotherapy (RT) or concomitant chemoradiotherapy. METHODS:From January 2001 to January 2003, 149 ...

journal_title：Oncology

authors： Fang FM,Tsai WL,Chien CY,Chiu HC,Wang CJ,Chen HC,Hsiung CY

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to evaluate the antitumor activity and safety of an epirubicin, cisplatin, and capecitabine (ECX) combination in patients with metastatic or advanced gastric cancer. PATIENTS AND METHODS:Patients with metastatic or advanced measurable gastric adenocarcinoma received ECX combina...

journal_title：Oncology

authors： Cho EK,Lee WK,Im SA,Lee SN,Park SH,Bang SM,Park DK,Park YH,Shin DB,Lee JH

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies in China and, due to the limited efficacy of currently available therapies, is responsible for a large number of deaths. IFN-alpha therapy has shown promise in the treatment of various forms of human cancer and is considered in the trea...

journal_title：Oncology

authors： Wu WZ,Sun HC,Gao YQ,Li Y,Wang L,Zhou K,Liu KD,Iliakis G,Tang ZY

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:Farnesyl diphosphate synthase (FPPs) produces FPP which is considered a branch-point intermediate in the synthesis of sterols and isoprenylated cellular metabolites. In this study we investigated whether detectable FPPs activity was present in human colorectal cancer (CRC), also evaluating in vitro the role o...

journal_title：Oncology

authors： Notarnicola M,Messa C,Cavallini A,Bifulco M,Tecce MF,Eletto D,Di Leo A,Montemurro S,Laezza C,Caruso MG

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND/OBJECTIVE:Clear cell renal cell carcinoma (CCRCC) is a malignant neoplasm frequently associated with an increase in circulating immune complexes (CIC). Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is a disease involving the chorioretinal structures of the eye, and it is commonly observe...

journal_title：Oncology

authors： Parmeggiani F,Costagliola C,D'Angelo S,Incorvaia C,Perri P,Sebastiani A

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Both irinotecan (CPT) and paclitaxel (Pac) are effective against non-small cell lung cancer (NSCLC), and besides, preclinical studies have demonstrated an additive or synergistic interaction between camptothecin and taxane. METHODS:We conducted a phase I/II study of combination chemotherapy consisting of Pa...

journal_title：Oncology

authors： Yamada K,Ikehara M,Tanaka G,Nomura I,Oshita F,Noda K

更新日期：2004-01-01 00:00:00

abstract：:We analyzed the differential gene expression in the pancreatic cancer cell line NP-18 upon induction of apoptosis caused by cyclin-dependent kinase inhibition triggered by either overexpression of the tumor suppressor gene p16(INK4A)using an adenoviral construction or incubation with the chemical inhibitors, roscoviti...

journal_title：Oncology

authors： Blasco F,Peñuelas S,Cascalló M,Hernández JL,Alemany C,Masa M,Calbó J,Soler M,Nicolás M,Pérez-Torras S,Gómez A,Tarrasón G,Noé V,Mazo A,Ciudad CJ,Piulats J

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVES:To assess whether the use of an organ-specific treatment could improve event-free survival (EFS) and overall survival as endpoints in testicular lymphoma in the early stage: IE and IIE. METHODS:Thirty-four patients were selected to be treated with orchiectomy following six cycles of anthracycline-based comb...

journal_title：Oncology

authors： Avilés A,Neri N,Huerta-Guzmán J,Pérez F,Fernández R

更新日期：2004-01-01 00:00:00

abstract：:Reported frequencies for microsatellite instability (MSI) in oesophageal cancer differ widely in the literature, perhaps due to the high incidence of loss of heterozygosity (LOH) in this cancer. Using high-resolution fluorescent microsatellite analysis (HRFMA), we analysed microsatellite alterations in detail in 50 Ja...

journal_title：Oncology

authors： Araki K,Wang B,Miyashita K,Cui Q,Ohno S,Baba H,Zhang RG,Sugimachi K,Maehara Y,Oda S

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:We performed a pilot study to evaluate the effect of the high-dose gemcitabine-cisplatin combination in a brief weekly regimen in the treatment of primary refractory diffuse large cell lymphoma with high or high-intermediate clinical risk. METHODS:Thirty patients refractory to first-line anthracycline-based ...

journal_title：Oncology

authors： Avilés A,Neri N,Huerta-Guzmán J,Fernández R

更新日期：2004-01-01 00:00:00

abstract：:Growth-regulated oncogene-1 (GRO-1) is an autocrine growth factor in melanoma and is a member of the CXC family of chemokines which promote chemotaxis of granulocytes and endothelia through binding to CXC receptor 2. A previous article noted that GRO-1 was upregulated in oral cancer using a genome-wide microarray appr...

journal_title：Oncology

authors： Shintani S,Ishikawa T,Nonaka T,Li C,Nakashiro K,Wong DT,Hamakawa H

更新日期：2004-01-01 00:00:00

abstract：:We examined the expression of p16, the CDKN2A gene product, in EBV-associated gastric carcinomas (EBV-GCs). EBV-GCs were identified by detecting EBV-encoded small RNA (EBER) using an in situ hybridization assay of paraffin-embedded tissue. Two non-EBV-GC cases for each EBV-GC case were selected, matched for age, sex, ...

journal_title：Oncology

authors： Koriyama C,Kitajima S,Nomoto M,Sueyoshi K,Itoh T,Eizuru Y,Yonezawa S,Akiba S

更新日期：2004-01-01 00:00:00